Grape seed extract lowered diastolic blood pressure about 2 mmHg across 19 trials, but the bottle's 16,000 mg is seed weight, not dose. Here is the evidence.
LDL cholesterol
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Red Yeast Rice for Cholesterol: The FDA Warning Behind the Supplement
Red yeast rice's active compound is chemically identical to a statin drug, which is why the FDA treats potent versions as an unapproved drug, not a supplement.