With 1,700 mcg of folate in the form of 5-MTHF, the metabolically active form of folic acid, our Optimized Folate formula helps to promote both cardiovascular and mental health.
Homocysteine is a metabolic byproduct that has been linked to both cardiovascular and cognitive health. The B vitamin folate aids in keeping homocysteine levels at normal ranges. 400 mcg of folate per day is the RDA for adults. The amount of L-Methylfolate in our product is 1,700 mcg.
1,700 mcg of folate per day can help maintain already healthy levels of the health biomarker homocysteine.
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- Delivers 1,700 mcg of the B vitamin folate
Folic acid is a common B-vitamin supplement. Healthy homocysteine levels that are already within the normal range are maintained by folate. Be proactive because homocysteine levels are an essential biomarker for both cardiovascular and mental health.
The RDA for folate for non-pregnant or lactating adults is 400 mcg a day. This formula delivers 1,700 mcg of 5-MTHF folate. Try our High Potency Optimized Folate product, which provides 8,500 mcg of 5-MTHF, if you're seeking for a greater dose. You can mix either formula with riboflavin, vitamin B6 in the form of pyridoxal 5'-phosphate or pyridoxine hydrochloride, and/or vitamin B12 in the form of methylcobalamin.
Serving Size 1 vegetarian tablet
| Country of Manufacture | United States |
|---|---|
| Product Condition | NewCondition |
| Feature | No |
| Color | No |
| Size | No |
| UPC Code | 737870193913 |
| GTIN | 737870193913 |
| Maker | Life Extension |
| Manufacturer Product ID | No |
| Quantity in Box/Display | No |
| Serving Size | No |
| Flavor | No |
| Scent | No |
| Gender | No |
| Expiry Date | No |
| Time Needed for Effectiveness | No |
| Dietary Factors | No |
| Product Features | No |
| Product Type | No |
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Questions:
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1voteA: L-methylfolate (5-MTHF) is the biologically active form of folate ready for the body to use. Folic acid is synthetic and requires conversion via the MTHFR enzyme. People with MTHFR genetic variations (40-60% of population) cannot efficiently convert folic acid, making L-methylfolate the smarter choice.Posted by on Saturday, May 2, 2026
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1voteA: DFE stands for Dietary Folate Equivalent — the standard measurement that accounts for differences in absorption between folate forms. 1700 mcg DFE of L-methylfolate equals 1000 mcg of actual L-methylfolate. This labeling helps consumers compare products accurately.Posted by on Saturday, May 2, 2026
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1voteA: Anyone with MTHFR gene variations, those seeking cardiovascular support through homocysteine management, women planning pregnancy, and anyone wanting reliable folate intake without folic acid. Take 1 tablet daily with food.Posted by on Saturday, May 2, 2026
